University of Montreal Hospital Research Centre

University of Montreal Hospital Research Centre

Integrated services for conducting early-phase clinical trials in oncology and neurology

University of Montreal Hospital Research Centre
Dr. Rahima Jamal - Hemato-oncologist and Director, Unit for Innovative Therapies University of Montreal Hospital Research Centre (CRCHUM)

Dr. Rahima Jamal
Hemato-oncologist and Director, Unit for Innovative Therapies
University of Montreal Hospital Research Centre (CRCHUM)

One of the most modern research organizations in North America, the University of Montreal Hospital Research Centre (CRCHUM) boasts early clinical research infrastructures that are highly competitive in Canada.

Areas of expertise

  • More than 60 investigators involved in early-phase clinical trials (phases I and II);
  • Early-phase trials in oncology and neurology, including for first-in-human drug trials;
  • Solid and hematological tumours such as head and neck cancer, melanoma, gynecological tumours, thoracic oncology, digestive oncology, breast cancer, prostate cancer, urologic oncology, lymphomas, etc.
  • Innovative oncology treatments: manipulation of the microbiota, immunomodulators, targeted therapies, immunocellular therapy, etc.;
  • Innovative neurology treatments: multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s disease, progressive supranuclear palsy, etc.


  • 15-person team dedicated to early-phase clinical studies (phases I and II) collaborating with more than 60 investigators;
  • Close collaboration with the CRCHUM’s translational research core facilities and laboratories;
  • Pharmacokinetic and pharmacodynamic studies;
    Correlative studies program providing a centralized biospecimen resource for clinical studies.


  • Secure unit dedicated to phase l and ll clinical trials, occupying 680 sq. metres of space;
  • 15 beds, including 4 closed-off rooms and 11 cubicles. These spaces are equipped with a multifunction computer station;
  • Secured laboratory for biospecimen management, handling and shipping;
  • More than 18 state-of-the-art scientific core facilities: animal facility, biobanks, cytometry, cellular imaging, experimental imaging, clinical immunomonitoring, metabolomics, microfluidics, molecular pathology, pharmacokinetics, cellular physiology, radiochemistry and cyclotron, transgenesis and animal modelling and CITADEL (the CHUM Center for the Integration and Analysis of Medical Data).

Investigators specializing in phase I trials


Dr. Francine Aubin – Hematologist and oncologist: gastrointestinal, colorectal, digestive and GIST cancers and ENT cancers

Dr. Jean-Pierre Ayoub — Hematologist and oncologist: gastrointestinal cancers and breast cancer

Dr. Karl Bélanger — Hematologist-oncologist: neuro-oncology, melanoma

Dr. Normand Blais — Hematologist-oncologist: medical oncology, targeted therapies, lung cancer, thrombosis

Dr. David Donath — Radiation oncologist: Department of Radiology, Radiation Oncology and Nuclear Medicine

Dr. Stéphane Doucet — Hematologist-oncologist: oncology and clinical research, malignant hematology, lymphoma

Dr. Rahima Jamal — Medical Director of the Unit for Innovative Therapies and hematologist-oncologist: melanoma, head and neck cancer, phase I and II clinical studies

Dr. Jean-Baptiste Latouff — Urological oncologist: kidney cancer, prostate cancer, molecular biology

Dr. Émilie Lemieux-Blanchard — Hematologist-oncologist: oncology and clinical research, multiple myeloma, neuro-oncology

Dr. Fred Saad — Urological oncologist: prostate cancer, tissue banks, prognostic markers for prostate cancer, hormone-refractory cancer

Dr. Denis Soulières — Hematologist-oncologist: ENT cancers, urologic oncology, prognostic and predictive genetic biomarkers, hemoglobinopathies, thalassemias

Dr. Simon TurcotteHepatobiliary surgeon: gastrointestinal cancer immunobiology, solid cancer immunotherapy, isolation and expansion of anti-tumour T cells; tumour antigen identification

Dr. Philip Wong — Radiation oncologist: translational research, genome, radiotherapy, sarcoma and palliative medicine


Dr. Sylvain Chouinard — Neurologist: movement disorders, Parkinson’s disease, Huntington’s disease, dystonia, tremor, Tourette syndrome, dyskinesias

Dr. Antoine Duquette — Neurologist: ataxias, dementias, genetics of neurological and psychiatric diseases, Parkinson’s disease, transgenic models

Dr. Geneviève Matte — Neurologist: ALS and motor neuron disorder


Josée Leclerc, M.Sc., DESS (advanced graduate diploma)
Senior Manager, clinical research
Phone: 514 890-8000, extension 15468